Focus on initiating and leading changes through digital transformation that aims to enhance the health and well-being of all Americans; by providing for effective health and human services and by fostering sound, sustained advances in the sciences underlying medicine, public health, and social services. Focus on strategic analysis; scalability, sustainability, feasibility, and most importantly marketability. Champion collaboration as an essential component to innovation and serve as a conduit to improve HHS ability to deliver mission outcomes, provide excellent service, and effectively steward taxpayer dollars on behalf of the American people. Embrace the big data paradigm and continue to evolve not only to change the lives of the American people, but aim to change the world through emerging technologies.